Published on Sun Aug 15 2021

Designing peptide drug with archaeal antimicrobial peptides against multidrug resistant bacterial biofilms and human diseases: an in silico approach

BANERJEE, S., CHAKRABORTY, S., MAJUMDER, K.

The adverse role of multi-drug resistant bacterial biofilms has posed a great risk to present world. Devising a therapy to impede such perilous effects is the need of the moment. We have designed a novel peptide therapy involving archaeal antimicrobial peptides.

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Abstract

The adverse role of multi-drug resistant bacterial biofilms accelerating human chronic diseases has posed a great risk to present world. Devising a therapy to impede such perilous effects is the need of the moment. So, in this study, we have designed a novel peptide therapy involving archaeal antimicrobial peptides. In silico predictions assign the peptide construct to be antigenic, non-allergenic, anti-cancerous and having stable physicochemical properties. Computational tools predict intracellular receptors in Escherichia coli and human to be possible binding targets of the construct. In silico docking of modelled peptide with targets, validated the predicted estimations. Coincidentally few human receptors binding strongly to the peptide, tend to be the widely recognized targets associated to human diseases with severe complications. Studies of conformational dynamics of peptide docked complexes with human and bacterial targets, indicated stable binding of the modelled construct. Certainly, the designed peptide could be a potent therapeutic against biofilms and human disorders.