Published on Thu Sep 30 2021

Variation in the response to malaria in Diversity Outbred mice

Gupta, A. S., Chevee, V., Kirosingh, A. S., Davis, N. M., Schneider, D. S.

We infected mice with Plasmodium chabaudi to better understand how the host response to infection can vary and to try to identify genetic loci responsible for this variation. We identified two loci correlating with binary traits: one on chromosome two was linked to undetectable parasite loads.

3
1
1
Abstract

We infected Diversity Outbred mice with Plasmodium chabaudi to better understand how the host response to infection can vary and to try to identify genetic loci responsible for this variation. We identified two loci correlating with binary traits: one on chromosome two was linked to undetectable parasite loads and another on chromosome ten which was linked to death. Though we tested many variable traits, none of those reached statistical significance using the 489 mice we tested.